Inhibition of glutamine synthetase activity by manganous ions in a cytosol extract of rat liver.
نویسندگان
چکیده
Glutamine synthetase activity in a cytosol extract of liver was inhibited non-competitively by Mn2+ ions. The apparent Ki for Mn2" in the presence of phosphate was 8 micro M. Inhibition of glutamine synthetase by intracellular Mn2+ may contribute to the very low rates of glutamine synthesis observed in perfused liver and isolated hepatocytes.
منابع مشابه
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 184 2 شماره
صفحات -
تاریخ انتشار 1979